A. I. Alford and K. D. Hankenson, Matricellular proteins: Extracellular modulators of bone development, remodeling, and regeneration, Bone, vol.38, issue.6, pp.749-757, 2006.
DOI : 10.1016/j.bone.2005.11.017

P. S. Rowe, P. A. De-zoysa, R. Dong, H. R. Wang, K. E. White et al., MEPE, a New Gene Expressed in Bone Marrow and Tumors Causing Osteomalacia, Genomics, vol.67, issue.1, pp.54-68, 2000.
DOI : 10.1006/geno.2000.6235

M. Macdougall, D. Simmons, T. T. Gu, and J. Dong, MEPE/OF45, a New Dentin/Bone Matrix Protein and Candidate Gene for Dentin Diseases Mapping to Chromosome 4q21, Connective Tissue Research, vol.60, issue.2-3, pp.320-330, 2002.
DOI : 10.3109/03008209509016988

K. Kawasaki and K. M. Weiss, Evolutionary genetics of vertebrate tissue mineralization: the origin and evolution of the secretory calcium-binding phosphoprotein family, Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, vol.249, issue.3, pp.295-316, 2006.
DOI : 10.1002/jez.b.21088

K. U. Ogbureke and L. W. Fisher, Expression of SIBLINGs and Their Partner MMPs in Salivary Glands, Journal of Dental Research, vol.83, issue.9, pp.664-670, 2004.
DOI : 10.1177/154405910408300902

K. U. Ogbureke and L. W. Fisher, Renal expression of SIBLING proteins and their partner matrix metalloproteinases (MMPs), Kidney International, vol.68, issue.1, pp.155-166, 2005.
DOI : 10.1111/j.1523-1755.2005.00389.x

J. Sodek, B. Ganss, and M. D. Mckee, Osteopontin, Critical Reviews in Oral Biology & Medicine, vol.11, issue.3, pp.279-303, 2000.
DOI : 10.1177/10454411000110030101

R. Patarca, R. A. Saavedra, and H. Cantor, Molecular and cellular basis of genetic resistance to bacterial infection: the role of the early T-lymphocyte activation-1/osteopontin gene, Crit. Rev. Immunol, vol.13, pp.225-246, 1993.

B. Ganss, R. H. Kim, and J. Sodek, Bone Sialoprotein, Critical Reviews in Oral Biology & Medicine, vol.10, issue.1, pp.79-98, 1999.
DOI : 10.1177/10454411990100010401

G. K. Hunter and H. A. Goldberg, Modulation of crystal formation by bone phosphoproteins: role of glutamic acid-rich sequences in the nucleation of hydroxyapatite by bone sialoprotein, Biochemical Journal, vol.302, issue.1, pp.175-179, 1994.
DOI : 10.1042/bj3020175

A. L. Boskey, M. Maresca, W. Ullrich, S. B. Doty, W. T. Butler et al., Osteopontin-hydroxyapatite interactions in vitro: inhibition of hydroxyapatite formation and growth in a gelatin-gel, Bone and Mineral, vol.22, issue.2, pp.147-159, 1993.
DOI : 10.1016/S0169-6009(08)80225-5

T. Kubota, M. Yamauchi, J. Onozaki, S. Sato, Y. Suzuki et al., Influence of an intermittent compressive force on matrix protein expression by ROS 172.8 cells, with selective stimulation of osteopontin, Archives of Oral Biology, vol.38, issue.1, pp.23-30, 1993.
DOI : 10.1016/0003-9969(93)90150-K

R. S. Carvalho, A. Bumann, J. L. Schaff, and L. C. Gerstenfeld, Predominant integrin ligands expressed by osteoblasts show preferential regulation in response to both cell adhesion and mechanical perturbation, Journal of Cellular Biochemistry, vol.10, issue.3, pp.497-508, 2002.
DOI : 10.1002/jcb.10031

M. Ishijima, S. R. Rittling, T. Yamashita, K. Tsuji, H. Kurosawa et al., Enhancement of Osteoclastic Bone Resorption and Suppression of Osteoblastic Bone Formation in Response to Reduced Mechanical Stress Do Not Occur in the Absence of Osteopontin, The Journal of Experimental Medicine, vol.9, issue.31, pp.399-404, 2001.
DOI : 10.1172/JCI8905

H. Yoshitake, S. R. Rittling, D. T. Denhardt, and M. Noda, Osteopontin-defi cient mice are resistant to ovariectomy-induced bone resorption, Proc. Natl. Acad. Sci. USA, pp.8156-8160, 1999.

G. Boivin and P. J. Meunier, The Degree of Mineralization of Bone Tissue Measured by Computerized Quantitative Contact Microradiography, Calcified Tissue International, vol.70, issue.6, pp.503-511, 2002.
DOI : 10.1007/s00223-001-2048-0

D. Amblard, M. H. Lafage-proust, A. Laib, T. Thomas, P. Ruegsegger et al., Tail Suspension Induces Bone Loss in Skeletally Mature Mice in the C57BL/6J Strain but Not in the C3H/HeJ Strain, Journal of Bone and Mineral Research, vol.27, issue.Suppl 1, pp.561-569, 2003.
DOI : 10.1359/jbmr.2003.18.3.561

N. L. Huq, K. J. Cross, M. Ung, and E. C. Reynolds, A review of protein structure and gene organisation for proteins associated with mineralised tissue and calcium phosphate stabilisation encoded on human chromosome 4, Archives of Oral Biology, vol.50, issue.7, pp.599-609, 2005.
DOI : 10.1016/j.archoralbio.2004.12.009

S. R. Rittling, H. N. Matsumoto, M. D. Mckee, A. Nanci, X. R. An et al., Mice Lacking Osteopontin Show Normal Development and Bone Structure but Display Altered Osteoclast Formation In Vitro, Journal of Bone and Mineral Research, vol.304, issue.7, pp.1101-1111, 1998.
DOI : 10.1359/jbmr.1998.13.7.1101

R. 1. Fisher, L. W. , and N. S. Fedarko, Six Genes Expressed in Bones and Teeth Encode the Current Members of the SIBLING Family of Proteins, Connective Tissue Research, vol.275, issue.1, pp.33-40, 2003.
DOI : 10.1074/jbc.M110757200

A. Bellahc-È-ne, N. Maloujahmoum, L. W. Fisher, H. Pastorino, E. Tagliabue et al., Expression of Bone Sialoprotein in Human Lung Cancer, Calcified Tissue International, vol.61, issue.3, pp.183-188, 1997.
DOI : 10.1007/s002239900320

H. Rangaswami, A. Bulbule, and G. C. Kundu, Osteopontin: role in cell signaling and cancer progression, Trends in Cell Biology, vol.16, issue.2, pp.79-87, 2006.
DOI : 10.1016/j.tcb.2005.12.005

A. Bellahcene, K. Bonjean, B. Fohr, N. S. Fedarko, F. A. Robey et al., Bone Sialoprotein Mediates Human Endothelial Cell Attachment and Migration and Promotes Angiogenesis, Circulation Research, vol.86, issue.8, pp.885-891, 2000.
DOI : 10.1161/01.RES.86.8.885

H. Y. Zhou, H. Takita, R. Fujisawa, M. Mizuno, and Y. Kuboki, Stimulation by bone sialoprotein of calcification in osteoblast-like MC3T3-E1 cells, Calcified Tissue International, vol.90, issue.5, pp.403-407, 1995.
DOI : 10.1007/BF00301610

L. F. Cooper, P. K. Yliheikkila, D. A. Felton, and S. W. Whitson, Spatiotemporal Assessment of Fetal Bovine Osteoblast Culture Differentiation Indicates a Role for BSP in Promoting Differentiation, Journal of Bone and Mineral Research, vol.266, issue.Suppl, pp.620-632, 1998.
DOI : 10.1359/jbmr.1998.13.4.620

M. Mizuno, T. Imai, R. Fujisawa, H. Tani, and Y. Kuboki, Bone Sialoprotein (BSP) is a Crucial Factor for the Expression of Osteoblastic Phenotypes of Bone Marrow Cells Cultured on Type I Collagen Matrix, Calcified Tissue International, vol.66, issue.5, pp.388-396, 2000.
DOI : 10.1007/s002230010078

J. Wang, H. Y. Zhou, E. Salih, L. Xu, L. Wunderlich et al., Site-Specific In Vivo Calcification and Osteogenesis Stimulated by Bone Sialoprotein, Calcified Tissue International, vol.86, issue.3, pp.179-189, 2006.
DOI : 10.1007/s00223-006-0018-2

J. A. Gordon, C. E. Tye, A. V. Sampaio, T. M. Underhill, G. K. Hunter et al., Bone sialoprotein expression enhances osteoblast differentiation and matrix mineralization in vitro, Bone, vol.41, issue.3, pp.462-473, 2007.
DOI : 10.1016/j.bone.2007.04.191

C. Raynal, P. D. Delmas, and C. Chenu, Bone sialoprotein stimulates in vitro bone resorption, Endocrinology, vol.137, pp.2347-2354, 1996.

P. Valverde, Q. Tu, and J. Chen, BSP and RANKL Induce Osteoclastogenesis and Bone Resorption Synergistically, Journal of Bone and Mineral Research, vol.19, issue.9, pp.1669-1679, 2005.
DOI : 10.1359/JBMR.050511

I. Nakamura, T. Duong-le, S. B. Rodan, and G. A. Rodan, Involvement of ??v??3 integrins in osteoclast function, Journal of Bone and Mineral Metabolism, vol.90, issue.6, pp.337-344, 2007.
DOI : 10.1007/s00774-007-0773-9

M. A. Chellaiah, N. Kizer, R. Biswas, U. Alvarez, J. Strauss-schoenberger et al., Osteopontin Deficiency Produces Osteoclast Dysfunction Due to Reduced CD44 Surface Expression, Molecular Biology of the Cell, vol.14, issue.1, pp.173-189, 2003.
DOI : 10.1091/mbc.E02-06-0354

A. Nagy, J. Rossant, R. Nagy, W. Abramow-newerly, and J. C. Roder, Derivation of completely cell culture-derived mice from early-passage embryonic stem cells., Proc. Natl. Acad. Sci. USA, pp.8424-8428, 1993.
DOI : 10.1073/pnas.90.18.8424

B. L. Hogan, M. Blessing, G. E. Winnier, N. Suzuki, and C. M. Jones, Growth factors in development: the role of TGF-beta related polypeptide signalling molecules in embryogenesis, Dev, pp.53-60, 1994.

V. David, N. Laroche, B. Boudignon, M. H. Lafage-proust, C. Alexandre et al., Noninvasive In Vivo Monitoring of Bone Architecture Alterations in Hindlimb-Unloaded Female Rats Using Novel Three-Dimensional Microcomputed Tomography, Journal of Bone and Mineral Research, vol.10, issue.Suppl 2, pp.1622-1631, 2003.
DOI : 10.1359/jbmr.2003.18.9.1622

J. E. Aubin, Osteoprogenitor cell frequency in rat bone marrow stromal populations: Role for heterotypic cell-cell interactions in osteoblast differentiation, Journal of Cellular Biochemistry, vol.13, issue.3, pp.396-410, 1999.
DOI : 10.1002/(SICI)1097-4644(19990301)72:3<396::AID-JCB9>3.0.CO;2-6

M. Bonyadi, S. D. Waldman, D. Liu, J. E. Aubin, M. D. Grynpas et al., Mesenchymal progenitor self-renewal defi ciency leads to age-dependent osteoporosis in Sca-1/Ly-6A null mice, Proc. Natl. Acad. Sci. USA, pp.5840-5845, 2003.

F. Solari, F. Flamant, Y. Cherel, M. Wyers, and P. Jurdic, The osteoclast generation: an in vitro and in vivo study with a genetically labelled avian monocytic cell line, J. Cell Sci, vol.109, pp.1203-1213, 1996.

S. Zhao and R. D. Fernald, Comprehensive Algorithm for Quantitative Real-Time Polymerase Chain Reaction, Journal of Computational Biology, vol.12, issue.8, pp.1047-1064, 2005.
DOI : 10.1089/cmb.2005.12.1047

X. Wang and B. Seed, A PCR primer bank for quantitative gene expression analysis, Nucleic Acids Research, vol.31, issue.24, p.154, 2003.
DOI : 10.1093/nar/gng154

. Ke, Targeted disruption of the osteoblast/osteocyte factor 45 gene (OF45) results in increased bone formation and bone mass, J. Biol. Chem, vol.278, pp.1998-2007, 2003.

Y. Ling, H. F. Rios, E. R. Myers, Y. Lu, J. Q. Feng et al., DMP1 Depletion Decreases Bone Mineralization In Vivo: An FTIR Imaging Analysis, Journal of Bone and Mineral Research, vol.49, issue.Suppl 1, pp.2169-2177, 2005.
DOI : 10.1359/JBMR.050815

J. Q. Feng, L. M. Ward, S. Liu, Y. Lu, Y. Xie et al., Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism, Nature Genetics, vol.67, issue.11, pp.1310-1315, 2006.
DOI : 10.1038/ng1905

W. Yang, S. E. Harris, P. Raw, J. Feng, and J. Gluhak-heinrich, MEPE over-expression in osteocytes of Dmp1 null mice by activation of the PKA/CREB pathway, J. Bone Miner. Res, vol.21, p.136, 2006.

S. Gajjeraman, K. Narayanan, J. Hao, C. Qin, and A. George, Matrix Macromolecules in Hard Tissues Control the Nucleation and Hierarchical Assembly of Hydroxyapatite, Journal of Biological Chemistry, vol.282, issue.2, pp.1193-1204, 2007.
DOI : 10.1074/jbc.M604732200

D. Harmey, K. A. Johnson, J. Zelken, N. P. Camacho, M. F. Hoylaerts et al., Elevated Skeletal Osteopontin Levels Contribute to the Hypophosphatasia Phenotype in Akp2???/??? Mice, Journal of Bone and Mineral Research, vol.166, issue.9, pp.1377-1386, 2006.
DOI : 10.1359/jbmr.060619

A. L. Boskey, L. Spevak, E. Paschalis, S. B. Doty, and M. D. Mckee, Osteopontin Deficiency Increases Mineral Content and Mineral Crystallinity in Mouse Bone, Calcified Tissue International, vol.71, issue.2, pp.145-154, 2002.
DOI : 10.1007/s00223-001-1121-z

R. J. Midura, A. Wang, D. Lovitch, D. Law, K. Powell et al., Bone Acidic Glycoprotein-75 Delineates the Extracellular Sites of Future Bone Sialoprotein Accumulation and Apatite Nucleation in Osteoblastic Cultures, Journal of Biological Chemistry, vol.279, issue.24, pp.25464-25473, 2004.
DOI : 10.1074/jbc.M312409200

J. P. Gorski, A. Wang, D. Lovitch, D. Law, K. Powell et al., Extracellular Bone Acidic Glycoprotein-75 Defines Condensed Mesenchyme Regions to be Mineralized and Localizes with Bone Sialoprotein during Intramembranous Bone Formation, Journal of Biological Chemistry, vol.279, issue.24, pp.25455-25463, 2004.
DOI : 10.1074/jbc.M312408200

N. S. Fedarko, A. Jain, A. Karadag, and L. W. Fisher, Three small integrin binding ligand N-linked glycoproteins (SIBLINGs) bind and activate specifi c matrix metalloproteinases, FASEB J, vol.18, pp.734-736, 2004.

A. Oldberg, A. Franzen, and D. Heinegard, Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence., Proc. Natl. Acad. Sci. USA, pp.8819-8823, 1986.
DOI : 10.1073/pnas.83.23.8819

M. J. Somerman, L. W. Fisher, R. A. Foster, and J. J. Sauk, Human bone sialoprotein I and II enhance fibroblast attachmentin vitro, Calcified Tissue International, vol.99, issue.1, pp.50-53, 1988.
DOI : 10.1007/BF02555169

A. Oldberg, A. Franzen, D. Heinegard, M. Pierschbacher, and E. Ruoslahti, Identifi cation of a bone sialoprotein receptor in osteosarcoma cells, J. Biol. Chem, vol.263, pp.19433-19436, 1988.

A. Miyauchi, J. Alvarez, E. M. Greenfi-eld, A. Teti, M. Grano et al., Recognition of osteopontin and related peptides by an alpha v beta 3 integrin stimulates immediate cell signals in osteoclasts, J. Biol. Chem, vol.266, pp.20369-20374, 1991.

F. P. Ross, J. Chappel, J. I. Alvarez, D. Sander, W. T. Butler et al., Interactions between the bone matrix proteins osteopontin and bone sialoprotein and the osteoclast integrin alpha v beta 3 potentiate bone resorption, J. Biol. Chem, vol.268, pp.9901-9907, 1993.

A. Bellahcene, M. P. Merville, and V. Castronovo, Expression of bone sialoprotein, a bone matrix protein, in human breast cancer, Cancer Res, vol.54, pp.2823-2826, 1994.

A. Bellahcene, S. Menard, R. Bufalino, L. Moreau, and V. Castronovo, Expression of bone sialoprotein in primary human breast cancer is associated with poor survival, International Journal of Cancer, vol.8, issue.4, pp.350-353, 1996.
DOI : 10.1002/(SICI)1097-0215(19960822)69:4<350::AID-IJC19>3.0.CO;2-9