Gadolinium chelates coated gold nanoparticles as contrast agents for both X-ray computed tomography and magnetic resonance imaging

Abstract : Functionalized gold nanoparticles were applied as contrast agents for both in vivo X-ray and magnetic resonance imaging. These particles were obtained by encapsulating gold cores within a multilayered organic shell which is composed of gadolinium chelates bound to each other through disulfide bonds. The contrast enhancement in MRI stems from the presence of gadolinium ions which are entrapped in the organic shell whereas the gold core provides a strong X-ray absorption. This study revealed that these particles suited for dual modality imaging freely circulate in the blood vessels without undesirable accumulation in lungs, spleen and liver.
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https://hal-ujm.archives-ouvertes.fr/ujm-00350670
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Submitted on : Wednesday, January 7, 2009 - 2:47:12 PM
Last modification on : Wednesday, December 12, 2018 - 3:29:50 PM

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  • HAL Id : ujm-00350670, version 1

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Christophe Alric, Jacqueline Taleb, Géraldine Le Duc, Celine Mandon, Claire Billotey, et al.. Gadolinium chelates coated gold nanoparticles as contrast agents for both X-ray computed tomography and magnetic resonance imaging. Journal of the American Chemical Society, American Chemical Society, 2008, 130 (18), pp.5908. ⟨ujm-00350670⟩

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