Gadolinium chelates coated gold nanoparticles as contrast agents for both X-ray computed tomography and magnetic resonance imaging

Christophe Alric (1) , Jacqueline Taleb (2) , Géraldine Le Duc (3) , Celine Mandon (2) , Claire Billotey (2) , Alice Lemeur-Herland (2) , Thierry Brochard (3) , Francis Vocanson (4) , Marc Janier (2) , Pascal Perriat (5) , Stéphane Roux (1) , Olivier Tillement (1)

1 LPCML - Laboratoire de Physico-Chimie des Matériaux Luminescents
2 CREATIS - Centre de Recherche et d'Application en Traitement de l'Image et du Signal
3 ESRF - European Synchrotron Radiation Facility
4 LHC - Laboratoire Hubert Curien
5 MATEIS - Matériaux, ingénierie et science [Villeurbanne]

Functionalized gold nanoparticles were applied as contrast agents for both in vivo X-ray and magnetic resonance imaging. These particles were obtained by encapsulating gold cores within a multilayered organic shell which is composed of gadolinium chelates bound to each other through disulfide bonds. The contrast enhancement in MRI stems from the presence of gadolinium ions which are entrapped in the organic shell whereas the gold core provides a strong X-ray absorption. This study revealed that these particles suited for dual modality imaging freely circulate in the blood vessels without undesirable accumulation in lungs, spleen and liver.

Domaines: Matériaux; Imagerie

Christophe Alric, Jacqueline Taleb, Géraldine Le Duc, Celine Mandon, Claire Billotey, et al.. Gadolinium chelates coated gold nanoparticles as contrast agents for both X-ray computed tomography and magnetic resonance imaging. Journal of the American Chemical Society, 2008, 130 (18), pp.5908-5915. ⟨10.1021/ja078176p⟩. ⟨ujm-00350670⟩