Big molecule ejection—SIMS vs. MALDI

Barbara J. Garrison , Tatiana Itina (1) , Leonid V. Zhigilei , Arnaud Delcorte , K. Krantzman , Y. Yingling , C. F. Mcquawa , E. Smiley , N. Winograd

1 LP3 - Laboratoire Lasers, Plasmas et Procédés photoniques

Using the results of molecular dynamics (MD) simulations, we discuss the question of whether the observed difference in mass limits in secondary ion mass spectrometry (SIMS) and matrix assisted laser desorption ionization (MALDI) are inherently related to the underlying physics of ejection or rather insufficient experimentation. The simulations show clearly that the physics of large molecule emission in SIMS and MALDI is very different. Consequently, we conclude that larger molecules can be ejected in MALDI than in SIMS.

Keywords: MALDI; Organic SIMS; Molecular dynamics; Computer simulation

Domains: Engineering Sciences [physics]; Chemical and Process Engineering

Barbara J. Garrison, Tatiana Itina, Leonid V. Zhigilei, Arnaud Delcorte, K. Krantzman, et al.. Big molecule ejection—SIMS vs. MALDI. Applied Surface Science, 2003, 203-204 (15), pp.69-71. ⟨10.1016/S0169-4332(02)00661-X⟩. ⟨ujm-00377617⟩