2008 SOR guidelines for the prevention and treatment of thrombosis associated with central venous catheters in patients with cancer: report from the working group.

P. Debourdeau D. Kassab Chahmi G. Le Gal 1 I. Kriegel E. Desruennes M.-C. Douard I. Elalamy 2 G. Meyer 3 P. Mismetti 4 M. Pavic M.-L. Scrobohaci H. Lévesque 5 J. M. Renaudin 6 D. Farge 7 Non Renseigné
1 GETBO - Groupe d'Etude de la Thrombose de Bretagne Occidentale
2 SCDCAP - Signalisation cellulaire, dynamique circulatoire et athérosclérose précoce
3 Ecole Vétérinaire de Toulouse
4 GRT (EA 3065) - Groupe de recherche sur la thrombose
5 Service de Médecine Interne
6 GD2P - Génomique, développement et pouvoir pathogène
7 Bases Moleculaires de l'Homeostasie Cutanee : Inflammation, Reparation et Cancer
Abstract : BACKGROUND: In view of the lack of recommendations on central venous catheter (CVC)-associated thrombosis in cancer patients, we established guidelines according to the well-standardized Standards, Options and Recommendations methodology. Material and methods: A literature review (1990-2007) on CVC-associated thrombosis was carried out. The guidelines were developed on the basis of the corresponding levels of evidence derived from analysis of the 36 of 175 publications selected. They were then peer reviewed by 65 independent experts. RESULTS: For the prevention of CVC-associated thrombosis, the distal tip of the CVC should be placed at the junction between the superior cava vein and right atrium; anticoagulants are not recommended. Treatment of CVC-associated thrombosis should be based on the prolonged use of low-molecular weight heparins. Maintenance of the catheter is justified if it is mandatory, functional, in the right position, and not infected, with a favorable clinical evolution under close monitoring; anticoagulant treatment should then be continued as long as the catheter is present. CONCLUSIONS: Several rigorous studies do not support the use of anticoagulants for the prevention of CVC-associated thrombosis. Treatment of CVC-associated thrombosis relies on the same principles as those applied in the treatment of established thrombosis in cancer patients.
Type de document :
Article dans une revue
Annals of Oncology, Oxford University Press (OUP), 2009, 20 (9), pp.1459-71. 〈10.1093/annonc/mdp052〉
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https://hal-ujm.archives-ouvertes.fr/ujm-00439715
Contributeur : Patrick Mismetti <>
Soumis le : mardi 8 décembre 2009 - 14:26:32
Dernière modification le : mardi 27 mars 2018 - 15:20:02

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UNIV-ST-ETIENNE | INRA | UPMC | UNIV-BREST | GETBO | USPC

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P. Debourdeau, D. Kassab Chahmi, G. Le Gal, I. Kriegel, E. Desruennes, et al.. 2008 SOR guidelines for the prevention and treatment of thrombosis associated with central venous catheters in patients with cancer: report from the working group.. Annals of Oncology, Oxford University Press (OUP), 2009, 20 (9), pp.1459-71. 〈10.1093/annonc/mdp052〉. 〈ujm-00439715〉

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