Predicting recurrences or major bleeding in cancer patients with venous thromboembolism. Findings from the RIETE Registry. - Archive ouverte HAL Access content directly
Journal Articles Thrombosis and Haemostasis Year : 2008

Predicting recurrences or major bleeding in cancer patients with venous thromboembolism. Findings from the RIETE Registry.

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1
Javier Trujillo-Santos
  • Function : Author
Gregorio Tiberio
  • Function : Author
Andrea Piccioli
  • Function : Author
Pierpaolo Di Micco
  • Function : Author
Paolo Prandoni
  • Function : Author
Manuel Monreal
Non Renseigné
  • Function : Author

Abstract

Cancer patients with acute venous thromboembolism (VTE) have an increased incidence of recurrences and bleeding complications while on anticoagulant therapy. Methods RIETE is an ongoing registry of consecutive patients with acute VTE. We tried to identify which cancer patients are at a higher risk for recurrent pulmonary embolism (PE), deep vein thrombosis (DVT) or major bleeding. Up to May 2007, 3,805 cancer patients had been enrolled in RIETE. During the first three months of follow-up after the acute, index VTE event, 90 (2.4%) patients developed recurrent PE, 100 (2.6%) recurrent DVT, 156 (4.1%) had major bleeding. Forty patients (44%) died of the recurrent PE,46 (29%) of bleeding. On multivariate analysis, patients aged <65 years (odds ratio [OR]: 3.0; 95% confidence interval [CI]: 1.9-4.9), with PE at entry (OR: 1.9; 95% CI: 1.2-3.1), or with <3 months from cancer diagnosis to VTE (OR: 2.0; 95% CI: 1.2-3.2) had an increased incidence of recurrent PE. Those aged <65 years (OR: 1.6; 95% CI: 1.0-2.4) or with <3 months from cancer diagnosis (OR: 2.4; 95% CI: 1.5-3.6) had an increased incidence of recurrent DVT. Finally, patients with immobility (OR: 1.8; 95% CI: 1.2-2.7), metastases (OR: 1.6; 95% CI: 1.1-2.3), recent bleeding (OR: 2.4; 95% CI: 1.1-5.1), or with creatinine clearance <30 ml/min (OR: 2.2; 95% CI: 1.5-3.4), had an increased incidence of major bleeding. With some variables available at entry we may identify those cancer patients with VTE at a higher risk for recurrences or major bleeding.
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Dates and versions

ujm-00439740 , version 1 (08-12-2009)

Identifiers

  • HAL Id : ujm-00439740 , version 1
  • PUBMED : 18766259

Cite

Javier Trujillo-Santos, José Antonio Nieto, Gregorio Tiberio, Andrea Piccioli, Pierpaolo Di Micco, et al.. Predicting recurrences or major bleeding in cancer patients with venous thromboembolism. Findings from the RIETE Registry.. Thrombosis and Haemostasis, 2008, 100 (3), pp.435-9. ⟨ujm-00439740⟩
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