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Université Jean Monnet – Saint-Etienne |  |
Journal articles
Safety and long-term outcome of a new concept for surgical adhesion-reduction strategies (Prevadh): a prospective, multicenter study.
Jean-Yves Mabrut
Jean-Pierre Favre
1
Bruno Desrousseaux
Jacques Chipponi
Jean-Pierre Arnaud
2
Jacques Domergue
3
J. P. Duffas
Gilles Fourtanier
4
Jean-Bernard Flament
5
Christian Gouillat
Stéphane Berdah
Georges Mantion
6
Pierre-Louis Fagniez
Gérard Champault
Jacques Baulieux
Jean-Yves Mabrut
Author
Jean-Pierre Favre 1
Author
Bruno Desrousseaux
Author
Jacques Chipponi
Author
Jean-Pierre Arnaud 2
Author
Jacques Domergue 3
Author
J. P. Duffas
Author
Gilles Fourtanier 4
Author
Jean-Bernard Flament 5
Author
Christian Gouillat
Author
Stéphane Berdah
Author
Georges Mantion 6
Author
1
I2MR - Institut de médecine moléculaire de Rangueil (Institut Louis Bugnard 1, avenue Jean Poulhes BP 84225 31432 TOULOUSE CEDEX 4 - France)
- UT3 - Université Toulouse III - Paul Sabatier (118 route de Narbonne - 31062 Toulouse - France)
- Université Fédérale Toulouse Midi-Pyrénées (41 Allée Jules Guesde, 31000 Toulouse - France)
- IFR150 (France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U858 (101, rue de Tolbiac, 75013 Paris - France)
2
TELEMME - Temps, espaces, langages Europe méridionale-Méditerranée (MMSH 5 Rue du château de l'Horloge - BP 647 13094 AIX EN PROVENCE CEDEX 2 - France)
- AMU - Aix Marseille Université : UMR7303 / UMR6570 / UMR9958 (Aix-Marseille Université Jardins du Pharo 58 Boulevard Charles Livon 13284 Marseille cedex 7 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR7303 / UMR6570 / UMR9958 (France)
3
ESPACE - Études des Structures, des Processus d’Adaptation et des Changements de l’Espace (98, boulevard Édouard Herriot BP 3209 06204 Nice Cedex 03 - France)
- Université de Provence - Aix-Marseille 1 (3, place Victor Hugo - 13331 Marseille Cedex 03 - France)
- UNSA - Université de Nice Sophia-Antipolis (Parc Valrose 06108, Nice cedex-2 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR6012 (France)
- AU - Avignon Université (74 rue Louis Pasteur - 84 029 Avignon cedex 1 - France)
- Université de la Méditerranée - Aix-Marseille 2 (58, boulevard Charles Livon - 13284 Marseille cedex 07 - France)
4
Chirurgie Générale et Digestive [Purpan] (Pôle Digestif - Place du Docteur Baylac - TSA 40031 - 31059 Toulouse cedex 9 Pavillon Dieulafoy - 5ème étage (Unité Pyrénées) - France)
- CHU Toulouse [Toulouse] (Hôtel-Dieu Saint Jacques 2, rue Viguerie TSA 80035 31059 Toulouse cedex 9 - France)
- Hôpital Purpan [Toulouse] (Place du Docteur Baylac
TSA 40031
31059 Toulouse cedex 9 - France)
- CHU Toulouse [Toulouse] (Hôtel-Dieu Saint Jacques 2, rue Viguerie TSA 80035 31059 Toulouse cedex 9 - France)
5
PhLAM - Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 (Campus Cité Scientifique - Bât. P5
- 2 Avenue Jean Perrin
- 59655 Villeneuve d’Ascq cedex - France)
- Université de Lille : UMR8523 (Lille - France)
- CNRS - Centre National de la Recherche Scientifique : UMR8523 (France)
6
WHO Collaborating Center on Prevention and Treatment of Human Echinococcosis (University of Franche-Comté 25030 Besançon cedex - France)
- UFC - Université de Franche-Comté (1 rue Goudimel 25030 Besançon cedex - France)
Abstract : BACKGROUND/AIMS: No agent has been consistently effective in preventing formation of peritoneal adhesions and postoperative bowel obstruction after abdominal surgery. The aim of this prospective multicenter study was to assess clinical safety and efficiency of a new adhesion-reduction barrier METHODOLOGY: Between September 2000 and April 2001, Prevadh was used in 78 patients. Operative procedures included 25 hepatic resections, 7 cholecystectomies, 32 colonic resections, 7 protectomies, 3 colostomy or recovery of continuity, 1 gynaecologic surgery and 3 others. Eleven patients were operated on by laparoscopy and 67 by laparotomy. RESULTS: The overall incidence of abscesses and wound complications was 2.4% and 9% respectively. After a mean follow-up of 36 months (range: 4-51 months), no patients experienced adverse events related to the adhesion barrier. Surgical reoperative procedures were performed in 10 patients for unrelated causes and no bowel obstruction occurred within the protected area. CONCLUSIONS: This study confirmed the safety of Prevadh adhesion barrier and suggested that this resorbable barrier might provide prevention from adhesion formation on peritoneal injured surfaces. However, a large randomized controlled trial remains necessary to prove the real effectiveness of adhesion barriers on clinical long-term outcome.
Document type :
Journal articles
Domain :
Complete list of metadata
https://hal-ujm.archives-ouvertes.fr/ujm-00440357
Contributor : Patrick Mismetti Connect in order to contact the contributor
Submitted on : Thursday, December 10, 2009 - 2:34:12 PM
Last modification on : Tuesday, January 18, 2022 - 4:16:03 PM
Contributor : Patrick Mismetti Connect in order to contact the contributor
Submitted on : Thursday, December 10, 2009 - 2:34:12 PM
Last modification on : Tuesday, January 18, 2022 - 4:16:03 PM
Identifiers
- HAL Id : ujm-00440357, version 1
- PUBMED : 18613399
Collections
CNRS | UNIV-FCOMTE | UNIV-ST-ETIENNE | MMSH | UNIV-AMU | TELEMME | UNIV-COTEDAZUR | UNIV-LILLE | UNIV-AVIGNON | UNIV-TLSE3 | UDL | ESPACE | PHLAM | POLITIQUES-PUBLIQUES
Citation
Jean-Yves Mabrut, Jean-Pierre Favre, Bruno Desrousseaux, Jacques Chipponi, Jean-Pierre Arnaud, et al.. Safety and long-term outcome of a new concept for surgical adhesion-reduction strategies (Prevadh): a prospective, multicenter study.. Hepato-Gastroenterology, Georg Thieme Verlag, 2008, 55 (82-83), pp.517-21. ⟨ujm-00440357⟩
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