[Incidence, prevalence and risk factors for a first infectious complication on a totally implantable venous-access port]

Abstract : BACKGROUND: Totally implantable venous-access ports (TIVAP) should present less risk of complications than central venous catheters over a long time period. AIMS: Firstly, the study's objective was to assess the prevalence and incidence of a first infectious complication on a TIVAP and secondly, to assess the risk factors associated with this first infection. METHODS: The authors made a longitudinal historical cohort study of patients with a TIVAP in 2003, in the Dijon University Hospital. RESULTS: Two hundred and nineteen patients (sex-ratio 1.9) were included, with a total follow-up of 92,773 patients-days. Ninety percent of the TIVAP were used for chemotherapy, 5% for antibiotic drug administration, 2% for parenteral nutrition and 3% for other reasons (recurrent blood transfusions, etc.). Overall, 34 (16.3%) out of 209patients presented with at least one infectious complication, with an incidence rate of 0.37infection/1,000patients-days. The 5-year cumulative probability to be free of infectious complication was only 62.8%. In multivariate analysis, only underlying hematological neoplasia (by contrast with solid tumors) was significantly associated to a higher risk of infectious complication. CONCLUSIONS: The infectious risk linked to the use of TIVAP is significant, higher in case of underlying hematological neoplasia and during the first months of use.
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Submitted on : Thursday, December 10, 2009 - 2:43:33 PM
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M. Crisinel, S. Mahy, P. Ortega-Debalon, Marielle Buisson, J.-P. Favre, et al.. [Incidence, prevalence and risk factors for a first infectious complication on a totally implantable venous-access port]. Médecine et Maladies Infectieuses, Elsevier Masson, 2009, 39 (4), pp.252-258. ⟨10.1016/j.medmal.2008.11.004⟩. ⟨ujm-00440366⟩

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