Time-resolved and spectral-resolved optical imaging to study brain hemodynamics in songbirds

Stephane Mottin 1, * Bruno Montcel 2 Hugues Guillet de Chatellus Stéphane Ramstein Clémentine Vignal 3 Nicolas Mathevon 3
* Corresponding author
1 LHC - Laboratoire Hubert Curien [Saint Etienne]
2 RMN et optique : De la mesure au biomarqueur
CREATIS - Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé
3 NAMC - Neurobiologie de l'apprentissage, de la mémoire et de la communication
Abstract : Contrary to the intense debate about brain oxygen dynamics and its uncoupling in mammals, very little is known in birds. In zebra finches, picosecond optical tomography (POT) with a white laser and a streak camera can measure in vivo oxy-hemoglobin (HbO2) and deoxy-hemoglobin (Hb) concentration changes following physiological stimulation (familiar calls and songs). POT demonstrated sufficient sub-micromolar sensitivity to resolve the fast changes in hippocampus and auditory forebrain areas with 250 μm resolution. The time-course is composed of (i) an early 2s-long event with a significant decrease in Hb and HbO2, respectively -0.7 μMoles/L and -0.9 μMoles/L (ii) a subsequent increase in blood oxygen availability with a plateau of HbO2 (+0.3μMoles/L) and (iii) pronounced vasodilatation events immediately following the end of the stimulus. One of the findings of our work is the direct link between the blood oxygen level-dependent (BOLD) signals previously published in birds and our results. Furthermore, the early vasoconstriction event and post-stimulus ringing seem to be more pronounced in birds than in mammals. These results in bird, a tachymetabolic vertebrate with a long lifespan, can potentially yield new insights for example in brain aging.
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Submitted on : Tuesday, October 4, 2011 - 11:52:05 AM
Last modification on : Tuesday, November 6, 2018 - 2:56:03 PM

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Stephane Mottin, Bruno Montcel, Hugues Guillet de Chatellus, Stéphane Ramstein, Clémentine Vignal, et al.. Time-resolved and spectral-resolved optical imaging to study brain hemodynamics in songbirds. Diffuse Optical Imaging III, May 2011, Munich, Germany. pp.11, ⟨10.1117/12.889799⟩. ⟨ujm-00628818⟩

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