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Université Jean Monnet – Saint-Etienne |  |
Conference papers
Time-resolved and spectral-resolved optical imaging to study brain hemodynamics in songbirds
Abstract : Contrary to the intense debate about brain oxygen dynamics and its uncoupling in mammals, very little is known in birds. In zebra finches, picosecond optical tomography (POT) with a white laser and a streak camera can measure in vivo oxy-hemoglobin (HbO2) and deoxy-hemoglobin (Hb) concentration changes following physiological stimulation (familiar calls and songs). POT demonstrated sufficient sub-micromolar sensitivity to resolve the fast changes in hippocampus and auditory forebrain areas with 250 μm resolution. The time-course is composed of (i) an early 2s-long event with a significant decrease in Hb and HbO2, respectively -0.7 μMoles/L and -0.9 μMoles/L (ii) a subsequent increase in blood oxygen availability with a plateau of HbO2 (+0.3μMoles/L) and (iii) pronounced vasodilatation events immediately following the end of the stimulus. One of the findings of our work is the direct link between the blood oxygen level-dependent (BOLD) signals previously published in birds and our results. Furthermore, the early vasoconstriction event and post-stimulus ringing seem to be more pronounced in birds than in mammals. These results in bird, a tachymetabolic vertebrate with a long lifespan, can potentially yield new insights for example in brain aging.
https://hal-ujm.archives-ouvertes.fr/ujm-00628818
Contributor : Stephane Mottin Connect in order to contact the contributor
Submitted on : Tuesday, October 4, 2011 - 11:52:05 AM
Last modification on : Wednesday, September 16, 2020 - 4:53:41 PM
Contributor : Stephane Mottin Connect in order to contact the contributor
Submitted on : Tuesday, October 4, 2011 - 11:52:05 AM
Last modification on : Wednesday, September 16, 2020 - 4:53:41 PM