Anticancer drug detection using a highly sensitive molecularly imprinted electrochemical sensor based on an electropolymerized microporous metalorganic framework - Université Jean-Monnet-Saint-Étienne Accéder directement au contenu
Article Dans Une Revue Talanta Année : 2015

Anticancer drug detection using a highly sensitive molecularly imprinted electrochemical sensor based on an electropolymerized microporous metalorganic framework

Résumé

A simple and highly sensitive approach for the detection of the anti-neoplastic drug gemcitabine is presented, based on a one-step electropolymerized molecularly imprinted microporous-metal-organic-framework. The sensitive layer was prepared by electropolymerization of the aniline moieties of p-aminothiophenol- gold nanoparticles on the surface of gold electrodes tethered with p-aminothiophenol, in the presence of gemcitabine as a template molecule. Experimental parameters that control the performance of the sensor were investigated and optimized. Under optimal conditions a calibration curve was obtained in the linear range from 3.8 fM to 38 nM with a limit of detection of 3 fM. The obtained imprinted sensor has the advantages of easy manufacture, high sensitivity and selectivity and good reproducibility. Furthermore the feasibility of the proposed technique has been investigated on spiked serum samples and infusion solution containing gemcitabine.
Fichier non déposé

Dates et versions

ujm-01121984 , version 1 (03-03-2015)

Identifiants

Citer

Anca Florea, Zhenzhong Guo, C. Cristea, François Bessueille, Francis Vocanson, et al.. Anticancer drug detection using a highly sensitive molecularly imprinted electrochemical sensor based on an electropolymerized microporous metalorganic framework. Talanta, 2015, 138, pp.71-76. ⟨10.1016/j.talanta.2015.01.013⟩. ⟨ujm-01121984⟩
102 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More