Presynaptic D2 Dopamine Receptors Control LTD Expression and Memory Processes in the Temporal Hippocampus

Jill Rocchetti (1) , Elsa Isingrini (2) , Gregory Dal Bo (1) , Sara Sagheby , Aurore Menegaux , François Tronche (3) , Daniel Levesque (4) , Luc Moquin (5) , Alain Gratton (1) , Tak Pan Wong (6) , Marcelo Rubinstein , Bruno Giros

1 McGill University = Université McGill [Montréal, Canada]
2 INCC - UMR 8002 - Centre Neurosciences intégratives et Cognition / Integrative Neuroscience and Cognition Center
3 NPS-15 - Expression des Gènes et comportement adaptatifs = Molecular Genetics, Neurophysiology and Behavior
4 Centre de recherche en Neuroscience
5 Douglas Mental Health University Institute [Montréal]
6 Brain Research Center

Dysfunctional mesocorticolimbic dopamine signaling has been linked to alterations in motor and reward-based functions associated with psychiatric disorders. Converging evidence from patients with psychiatric disorders and use of antipsychotics suggests that imbalance of dopamine signaling deeply alters hippocampal functions. However, given the lack of full characterization of a functional mesohippocampal pathway, the precise role of dopamine transmission in memory deficits associated with these disorders and their dedicated therapies is unknown. In particular, the positive outcome of antipsychotic treatments, commonly antagonizing D2 dopamine receptors (D2Rs), on cognitive deficits and memory impairments remains questionable.

Keywords: Antipsychotics; D(2) dopamine receptors; LTD; Memory; Neuronal plasticity; Temporal hippocampus

Domains: Life Sciences [q-bio]

Jill Rocchetti, Elsa Isingrini, Gregory Dal Bo, Sara Sagheby, Aurore Menegaux, et al.. Presynaptic D2 Dopamine Receptors Control LTD Expression and Memory Processes in the Temporal Hippocampus. Biological Psychiatry, 2015, 77 (6), pp.513-525. ⟨10.1016/j.biopsych.2014.03.013⟩. ⟨hal-03389601⟩